Chili peppers (Capsicum annuum) are used across the globe as an ingredient for spicy foods. Their hot pungent taste is attributed to a compound called capsaicin. However, there’s so much more to this compound than the kick that it gives to food. Researchers from Jawaharlal Nehru Technological University, Shadan College of Pharmacy, and Geethanjali College of Pharmacy in India have found that capsaicin has potent antihyperglycemic properties that are synergistic with the beneficial effects of the antidiabetic drug gliclazide.
When taking oral medications, one of the most important things to consider is the food that’s being consumed with it. This is because there are potential interactions that may occur between them that could lead to changes in food or drug metabolism, nutrient absorption, drug efficacy, and the risk of side effects. Previously, it was observed that capsaicin, the active ingredient in chili peppers, had negative effects on the circulation of drugs like galantamine and simvastatin. Therefore, before using capsaicin as a natural remedy for diseases like diabetes, it should first be tested for potential interactions with medications that it could possibly be used with.
Gliclazide is a drug commonly used by patients with Type 2 diabetes due to its ability to lower blood sugar levels. However, it has the potential to cause side effects like dizziness, nausea, diarrhea, and abdominal pain.
In this study, which was published in the journal Pharmacognosy Research, the researchers wanted to determine the antihyperglycemic effects of capsaicin as well as its potential interactions with gliclazide. To do this, they used albino rats (normal and diabetic) and albino rabbits (diabetic), which they divided into the following groups:
Group I – Normal control
Group II – Diabetic control
Group III – Gliclazide
Group IV – Capsaicin
Group V – Gliclazide and capsaicin
The researchers used parameters like blood sugar, insulin, and gliclazide level, which they determined from blood samples, to evaluate antihyperglycemic effects and interactions. They also determined beta-cell function. Their results revealed that capsaicin had potent antihyperglycemic activity in diabetic rats and rabbits, as exhibited by a decrease in blood sugar and an increase in insulin level and beta-cell function. In addition to this, capsaicin did not have a hypoglycemic effect in normal rats, unlike gliclazide.
It was also observed that treating the animal models with both gliclazide and capsaicin led to a more significant reduction in blood sugar levels and a greater increase in insulin levels and beta-cell function in the animals. These suggest that the two of them have synergistic effects, which the researchers attributed to the inhibition of enzymes that metabolize gliclazide by capsaicin.
Overall, the results of this study suggest that chili peppers have potential use as natural remedies for diabetes because of the antihyperglycemic activity of its active ingredient capsaicin.
Other benefits of capsaicin
Even if you don’t have diabetes, there are many other reasons to eat chili peppers. Some of the health benefits that you can enjoy from these include the following:
Pain relief — The capsaicin in chili peppers are also great for relieving pain. Eating a lot of chili peppers can increase your tolerance to pain since capsaicin binds to pain receptors and damages them, making them insensitive.
Weight loss — Capsaicin has thermogenic properties so eating more of it can reduce your cravings and increase your metabolism, helping you burn more calories.
Lower risk of cardiovascular disease — Chili peppers are rich in potassium, which relaxes blood vessels so that blood can flow properly. They also contain large amounts of niacin that can improve cholesterol levels and consequently reduce the risk of cardiovascular disease.
Improved immunity — Eating chili peppers can boost your immune system since they are rich in vitamin A, which maintains the health of the respiratory, intestinal, and urinary tracts.
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The goal of this policy is to make explicit the information we gather on our customers and users, how we will use it, and how we will not. This policy is unfortunately longer than we would like, but we must unambiguously address all the relevant cases. We will try and keep the language simple and direct as much as possible.
Part I – Information ITMC.com collects and controls
This part deals with how ITMC collects and uses information about website visitors, potential customers, users of ITMC's products and services, and others who contact ITMC through forms or email addresses published on or linked to our websites.
Part II – General
We collect information about you only if we need the information for some legitimate purpose. ITMC will have information about you only if (a) you have provided the information yourself or (b) ITMC has automatically collected the information. Below we describe the various scenarios that fall under each of those three categories and the information collected in each one.
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Information that we collect automatically
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In addition to the purposes mentioned above, we may use your information for the following purposes:
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If you are in the European Economic Area (EEA), you have the following rights with respect to information that ITMC holds about you. ITMC undertakes to provide you the same rights no matter where you choose to live.
Right to access: You have the right to access (and obtain a copy of, if required) the categories of personal information that we hold about you, including the information's source, purpose and period of processing, and the persons to whom the information is shared
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Right to restriction of processing: You may also have the right to request to restrict the use of your information in certain circumstances, such as when you have objected to our use of your data but we need to verify whether we have overriding legitimate grounds to use it.
Right to data portability: You have the right to transfer your information to a third party in a structured, commonly used and machine-readable format, in circumstances where the information is processed with your consent or by automated means.
Right to object: You have the right to object to the use of your information in certain circumstances, such as the use of your personal information for direct marketing.
Right to complain: You have the right to complain to the appropriate supervisory authority if you have any grievance against the way we collect, use or share your information. This right may not be available to you if there is no supervisory authority dealing with data protection in your country.
Our products and services are not directed to individuals under 13. ITMC does not knowingly collect personal information from children who are under 13 years of age. If we become aware that a child under 13 has provided us with personal information, we will take steps to delete such information. If you believe that a child under 13 years has provided personal information to us, please write to firstname.lastname@example.org with the details, and we will take the necessary steps to delete the information we hold about that child.
At ITMC, we take data security very seriously. We have taken steps to implement appropriate administrative, technical & physical safeguards to prevent unauthorized access, use, modification, disclosure or destruction of the information you entrust to us. If you have any concerns regarding the security of your data, we encourage you to write to us at reply@ITMC.com with any questions.
By accessing or using our products and services or otherwise providing personal information or service data to us, you consent to the processing, transfer, and storage of your personal information or Service Data within the United States of America, the European Economic Area (EEA) and other countries where ITMC operates. Such transfer is subject to a group company agreement that is based on EU Commission's Model Contractual Clauses.
We offer publicly accessible blogs and forums on our websites. Please be aware that any information you provide on these blogs and forums may be used to contact you with unsolicited messages. We urge you to be cautious in disclosing personal information in our blogs and forums. ITMC is not responsible for the personal information you elect to disclose publicly. Your posts and certain profile information may remain even after you terminate your account with ITMC. To request the removal of your information from our blogs and forums, you can contact us at email@example.com
Our websites include social media widgets such as Twitter "tweet" buttons that let you share articles and other information. These widgets may collect information such as your IP address and the pages you navigate in the website, and may set a cookie to enable the widgets to function properly. Your interactions with these widgets are governed by the privacy policies of the companies providing them.
We may be required by law to preserve or disclose your personal information and service data to comply with any applicable law, regulation, legal process or governmental request, including to meet national security requirements.
We may disclose personal information and service data to a third party if we believe that such disclosure is necessary for preventing fraud, investigating any suspected illegal activity, enforcing our agreements or policies, or protecting the safety of our users.
You may also contact us at: